scarfix

All the scars healing sequence of events began when the scar occurred. That is where the normal functional tissue (skin) is replaced by connective tissue (scar). Healing characterized by migration of specialized cells into the wound site. Healing is a complex process that produces dynamic recovery anatomical continuity and function.

Skin regeneration occurs when there is loss of structure and function. Our bodies have a sophisticated capacity to replace the network by replacing exactly what was there before the damage. Forms of lower life, such as salamander and crab, can regenerate tissue in this way. Throughout millions of years ago, we have lost this ability and can only recover a limited amount of tissue damaged by the process of regeneration.

Normal repairs are examples where re-established balance between formation and remodeling. These are the most typical response of human experience of pathological tissue damage stands in sharp contrast to normal repair response. In excessive healing there is an excessive accumulation of connective tissue resulting in tissue changes and, thus, loss of function. Fibrosis, structure, adhesion and contractures is a consequence of excessive healing. Keloids and hypertrophic wound in the skin fibrosis is an example. Contraction is part of the normal healing process but if excessive, becomes pathological and is called contracture.

Lack of healing is the opposite of fibrosis; was there when there is abnormally low precipitation connective tissue matrix and weaken the network to the point where it could fall apart. Uncurable chronic ulcers is an example of the lack of healing. When an injury occurs, a movement of different cells come soon and the complex healing process begins only when it happens.

Normal healing begins with hemostasis and coordinated process of accumulation of fibrin, which began the cascade of inflammation cells, characterized by neutrophils, macrophages and lymphocytes in the damaged tissue. This is followed by migration and proliferation of fibroblasts and collagen accumulation, and finally remodeling by collagen cross and scar maturation. Although this coordinated sequence of events leading to normal wound healing, pathological reactions that cause fibrosis or chronic ulcers can occur if any part of the healing cascade are changed.